Monitoring for successful treatment
Treatment of Lyme disease is not short. A minimal
treatment period of ceftriaxone for mild Lyme would be at least 3 months.
Minimal treatment with orals will be many many months even for mild Lyme
Your patient should run a diary. I get my patients to
run one along the same lines as a 10 point pain diary, and each morning to
rate how they felt the previous day. This will help to give a guide to what is
working and what is not.
Secondly the CD57 test
Critical update Dec 2nd 2010 see
CD57 Test page
The CD57 lymphocyte is currently the only laboratory
indicator of success in treating Lyme disease. It is done by flow cytometry
and can be ordered at limited laboratories here in Australia as part of a LSM
request. Contact author for information on where.
Refer to the page CD57 Test for detailed
information on CD57+ NK cells
As treatment progresses, if
successful, the count will rise. There are as yet no accepted standards
of a count that signifies successful treatment but I am sure we will see that
soon. Critical update on this topic.
Here is a study that shows some interesting figures on the rising CD57
value with treatment http://www.ncbi.nlm.nih.gov/pubmed/11222912
Thirdly how long is treatment?
and for some patients it may be 1-2 years including
intravenous therapy. Liken it to the treatment time of TB.
At the end of treatment the patient in theory should
have an IgG western blot that is positive